First Trimester
IN THIS LESSON
Video content, worksheets, practice problems and more
Lesson 17: SN2, SN1, E2, E1 Review Session
I. Introduction
Overview of SN2, SN1, E2, and E1 reactions.
Importance in organic synthesis and reaction mechanisms.
II. SN2 Reaction Review
Mechanism recap: Bimolecular nucleophilic substitution.
Tips for identifying SN2 favorable conditions: Less substituted substrates, strong nucleophiles.
Pearl of Wisdom: "In SN2 reactions, the nucleophile attacks from the backside, leading to inversion of stereochemistry."
III. SN1 Reaction Review
Mechanism and carbocation stability.
Factors influencing SN1 pathway: Solvent polarity, leaving group ability.
Pearl of Wisdom: "SN1 reactions proceed via carbocation intermediates, allowing for both inversion and retention of stereochemistry."
IV. E2 Reaction Review
Bimolecular elimination mechanism.
Zaitsev's rule and Hofmann elimination: Predicting major and minor alkene products.
Pearl of Wisdom: "E2 reactions are favored by strong bases and involve simultaneous bond formation and breaking."
V. E1 Reaction Review
Unimolecular elimination mechanism.
Carbocation stability and reaction conditions.
Pearl of Wisdom: "E1 reactions proceed via a carbocation intermediate, often favoring the formation of the most stable alkene."
VI. Comparative Analysis
Contrasting SN2 vs. SN1 and E2 vs. E1 reactions.
Practical examples and case studies highlighting selectivity and reaction conditions.
Pearl of Wisdom: "Understanding the subtle differences between SN2/SN1 and E2/E1 can significantly impact reaction outcomes in synthesis."
VII. Conclusion
Summary of key concepts and mechanisms.
